ALCOHOL INHIBITS THE METABOLISM OF DIMETHYL FUMARATE TO THE ACTIVE METABOLITE RESPONSIBLE FOR DECREASING RELAPSE FREQUENCY IN THE TREATMENT OF MULTIPLE SCLEROSIS

Dimethyl fumarate (DMF) is a first-line prodrug for the treatment of relapsing-remitting multiple sclerosis (RRMS) that is completely metabolized to monomethyl fumarate (MMF), the active metabolite, before reaching the systemic circulation.Its metabolism has been proposed to be due to ubiquitous bilstein shocks jeep xj esterases in the intestines a

ABSTRACTPolyhydroxybutyrate (PHB) is a renowned biodegradable plastic that do not quest fryer release any toxins or residues in the environment like petroleum based plastics.In the present study, 50 bacteria isolated from mangrove niche, Saudi Arabia, were screened for maximum PHB production.All the 50 strains showed positive for PHB production, of

In agroforestry systems (AFS), trees shade the understory crop to a certain extent.Potato is considered a shade-tolerant crop and was thus tested under the given total solar irradiance and climatic conditions of Southwestern Germany for its potential suitability in an AFS.To gain a better understanding of the effects of shade on growth, yield borst